Endocrine Abstracts

Loss of beta cell mass in the pancreas characterises type 1 and late-stage type 2 diabetes, resulting in a reduction of insulin levels. The pancreas has a very limited regenerative potential during homeostasis. Despite its quiescent nature, recent in vivo models suggest that a certain degree of regeneration and cellular interconversion is possible in the adult pancreas. The molecular regulation of this plasticity shares remarkable similarities with pancreas beta cell different...